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Fully funded PhD. Developing quantum biosensing GPCR drug discovery platform.
G protein coupled receptor coordinate functions of our body by transmitting extracellular hormonal to the inside of the cell. GPCRs offer...
PhD project. GPCR on-a-chip: quantum biosensor for drug discovery
The goal of this project is to develop quantum biosensors for drug discovery at single molecule level. Quantum sensing detects changes in...
PhD project: Role of GPCR autoantibodies in auto-immune hepatitis
Short read: The project is focused on identification of autoantibodies against a panel of inflammation related GPCRs in patient samples...
PhD project: CryoEM structure of cannabinoid receptor CB2 with biased ligands
BBSRC-funded PhD project in the group of Prof. Dmitry Veprintsev at the University of Nottingham. This is a joint project with Dr. David...
Two PhD positions
PhD opportunities, deadlines 09.01.22 and 07.01.22: 1) MRC AIM funded project with Neil Morgan (University of Birmingham), focusing on...
PhD position: Machine Learning guided design of GPCR ligands with desired pharmacology.
Adrenoceptors are G protein coupled receptors that mediate the action of adrenalin on heart rate or dilation of airways. The project will...

What makes a GPCR agonist an agonist and antagonist an antagonist?
“Prediction of ligand-receptor pharmacological activities using a combined docking and machine learning approach” by Mireia Jimenez-Roses...

Diverse chemotypes drive biased signaling by cannabinoid receptors
Our latest BioRxiv preprint describing a set of 35 cannabinoid ligands with full ADME properties dialling the signalling bias in a...
Edward Jobson and Akhil Hanmantgad join us for their BMedSci projects.
Edward and Akhil will focus on genetic basis for GPCR-related diseases.

ThermoBRET: our latest method to measure protein stability in unpurified samples.
Happy to share our latest ThermoBRET method to measure protein stability in unpurified samples. It is based on BRET between a novel...

Measuring GPCR thermostability in crude lysates - our latest preprint on bioRxiv
https://www.biorxiv.org/content/10.1101/2020.07.07.191957v1 Congratulations David Tippett - our star summer student - with his first...
Welcome to Zoe Tran and Rohini Srivastava.
Zoe and Rohini are joining the Veprintsev lab this summer to complete their master research projects as part of the Drug discovery and...
Our preprint showing solubilisation of the β2AR using the polymer DIBMA is now available.
https://www.biorxiv.org/content/10.1101/2020.06.29.171512v1
Congratulations Leire!
Congratulations to Leire Borrega on being awarded an EMBO short term fellowship to help support her work in the Veprintsev lab....
Check out our new peer reviewed protocol on high-throughput site directed scanning mutagenesis!
Our protocol for high-throughput site directed scanning mutagenesis using our two fragment PCR approach, alanine scanning software and...
Funded PhD positions available
As part of the BBSRC MIBPT program Dr C Gorvin and Professor D Veprintsev are are advertising a PhD position 'Understanding how GPCRs...

Fluorescent CB2 probes preprints on ChemRxiv!
Our two papers describing the development of fluorescent CB2 ligands are published on ChemRxiv. Congratulations to all collaborators!...


Asuman Bunsuz joins the Veprintsev lab
Asuman Bunsuz joins the lab to study the molecular basis of efficacy of GPCR pharmacological ligands by combining computational and...


Sean Cullum joins the Veprintsev lab
He will study the molecular basis of allosteric modulation.
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