PhD position: Machine Learning guided design of GPCR ligands with desired pharmacology.Adrenoceptors are G protein coupled receptors that mediate the action of adrenalin on heart rate or dilation of airways. The project will...
What makes a GPCR agonist an agonist and antagonist an antagonist? “Prediction of ligand-receptor pharmacological activities using a combined docking and machine learning approach” by Mireia Jimenez-Roses...
Diverse chemotypes drive biased signaling by cannabinoid receptorsOur latest BioRxiv preprint describing a set of 35 cannabinoid ligands with full ADME properties dialling the signalling bias in a...
Edward Jobson and Akhil Hanmantgad join us for their BMedSci projects. Edward and Akhil will focus on genetic basis for GPCR-related diseases.
ThermoBRET: our latest method to measure protein stability in unpurified samples. Happy to share our latest ThermoBRET method to measure protein stability in unpurified samples. It is based on BRET between a novel...
Measuring GPCR thermostability in crude lysates - our latest preprint on bioRxivhttps://www.biorxiv.org/content/10.1101/2020.07.07.191957v1 Congratulations David Tippett - our star summer student - with his first...
Welcome to Zoe Tran and Rohini Srivastava. Zoe and Rohini are joining the Veprintsev lab this summer to complete their master research projects as part of the Drug discovery and...
Our preprint showing solubilisation of the β2AR using the polymer DIBMA is now available. https://www.biorxiv.org/content/10.1101/2020.06.29.171512v1
Congratulations Leire!Congratulations to Leire Borrega on being awarded an EMBO short term fellowship to help support her work in the Veprintsev lab....
Check out our new peer reviewed protocol on high-throughput site directed scanning mutagenesis!Our protocol for high-throughput site directed scanning mutagenesis using our two fragment PCR approach, alanine scanning software and...
Funded PhD positions available As part of the BBSRC MIBPT program Dr C Gorvin and Professor D Veprintsev are are advertising a PhD position 'Understanding how GPCRs...
Fluorescent CB2 probes preprints on ChemRxiv!Our two papers describing the development of fluorescent CB2 ligands are published on ChemRxiv. Congratulations to all collaborators!...
Asuman Bunsuz joins the Veprintsev labAsuman Bunsuz joins the lab to study the molecular basis of efficacy of GPCR pharmacological ligands by combining computational and...
