What makes a GPCR agonist an agonist and antagonist an antagonist?

“Prediction of ligand-receptor pharmacological activities using a combined docking and machine learning approach” by Mireia Jimenez-Roses et al.

AI-based one-line summary “Ligands exert their action on GPCRs via the interactions they make in the ligand binding pocket that mediate their action.”

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PhD opportunities, deadlines 09.01.22 and 07.01.22: 1) MRC AIM funded project with Neil Morgan (University of Birmingham), focusing on characterisation of GPCR variants involved in bleeding disorders.