Diverse chemotypes drive biased signaling by cannabinoid receptors
Our latest BioRxiv preprint describing a set of 35 cannabinoid ligands with full ADME properties dialling the signalling bias in a rheostat-like manner.
G protein coupled receptor coordinate functions of our body by transmitting extracellular hormonal to the inside of the cell. GPCRs offer a tremendous potential for developing novel therapeutics, but
The goal of this project is to develop quantum biosensors for drug discovery at single molecule level. Quantum sensing detects changes in motion and electric and magnetic fields at the atomic level. I
Short read: The project is focused on identification of autoantibodies against a panel of inflammation related GPCRs in patient samples and evaluation of specific therapeutic interventions counteracti