What we study

G protein-coupled receptors (GPCRs) represent the most abundant class of integral membrane proteins in the human genome. They account for roughly 40% of all prescription drugs, aimed at treating various diseases such as cardiac dysfunction, obesity, asthma, and others. In the Veprintsev lab, we develop approaches for incorporation of protein and systems dynamics GPCRs into drug discovery. The projects range from applying protein engineering to map allosteric connections in GPCRs, structural studies of ligand-receptor complexes, studying kinetics of signalling, to linking structural and pharmacological properties of ligands with receptor structure and signalling using advanced computational techniques.