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Structural and biophysical pharmacology of G protein-coupled receptors (GPCRs)

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What we study

G protein-coupled receptors (GPCRs) represent the most abundant class of integral membrane proteins in the human genome. They account for roughly 40% of all prescription drugs, aimed at treating various diseases such as cardiac dysfunction, obesity, asthma, and others. In the Veprintsev lab, we develop approaches for incorporation of protein and systems dynamics GPCRs into drug discovery. The projects range from applying protein engineering to map allosteric connections in GPCRs, structural studies of ligand-receptor complexes, studying kinetics of signalling, to linking structural and pharmacological properties of ligands with receptor structure and signalling using advanced computational techniques.

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The Veprintsev lab is part of COMPARE (Centre of Membrane Proteins and Receptors), a unique collaboration between the Universities of Birmingham and Nottingham. Bringing together leading researchers to develop novel methods for visualising single membrane proteins, as well as identifying new approaches for the prevention and treatment of cardiovascular disease, respiratory disease and cancer angiogenesis.

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